Sprague Dawley rat Crl:CD(SD)-KO(Gnal*1)44Hpn/Hpn


Available to order

International strain nameSprague Dawley rat Crl:CD(SD)-KO(Gnal*1)44Hpn/Hpn
Alternative nameCrl:CD(SD)-KO(Gnal*1)44Hpn/Hpn
Strain typeEndonuclease-mediated
Allele/Transgene symbolGnal splicing variant 2
Gene/Transgene symbolGnal

Information from provider

ProviderHuu Phuc Nguyen
Provider affiliationInstitute of Medical Genetics and Applied Genomics, University of Tuebingen
Genetic informationGnal knockout rats were generated by CRISPR/Cas9 technology. Exon1 of rat Gnal splicing variant 2 was targeted, resulting in a deletion of 1 base pair that corresponds to position 44 downstream of the translation start point ATG of the Gnal splicing variant 2. CRISPR technology details: self-synthesized Cas9 mRNA using px 330 vector, applying T7 transcription kit followed by Poly-Adenylation and Capping. No sequencing performed, whether Cas9 has been inserted into the rat genome is unknown.
Phenotypic informationHomozygous:
Approximately 25% body weight reduction; Smaller body size; Hyperactivity; Better rotarod performance than wild-type littermates.

No body weight change; No body size change; Hypo-activity; Worse rotarod performance than wild-type littermates.
Breeding historyOutbreeding for approximately 16 generations
ReferencesNone available
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous rat Sprague-Dawley , wild-type rat Sprague-Dawley
Stage of embryos2-cell

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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