Available to order

International strain nameB6.129S2-H2-Ab1tm1Doi/DoiOrl
Alternative nameAbeta°
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolH2-Ab1tm1Doi,
Gene/Transgene symbolH2-Ab1

Information from provider

ProviderDiane MATHIS
Provider affiliationLGME Universite
Phenotypic informationMutant mice deficient in histocompatibility 2, class II antigen A, beta 1 (MHC class II A beta, H2-Ab1) gene. H2-Ab1 gene mutation obtained by homologous recombination (insertion of neomycin-resistance gene cassette into the second exon) in ES cells from 129S2/SvPas, yet deficient in the MHC complex. The animals show a complete lack of class II molecules and an almost total absence of CD4+ lymphocytes. Immune responses are much altered or lacking.
Breeding history129S2/SvPas ES cells; 9 generations of backcross with C57BL/6, then intercross.
  • Mice lacking MHC class II molecules.;Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D, ;1991;Cell;66;1051-66; 1909605

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6J, wild-type C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (allele matching)
  • insulitis / MGI
  • abnormal neuron proliferation / MGI
  • abnormal immune system morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal immune system cell morphology / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • reduced fertility / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell physiology / MGI
  • abnormal immune system organ morphology / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to parasitic infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • abnormal lymph node cell ratio / MGI

Literature references

  • Mice lacking MHC class II molecules.;Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D, ;1991;Cell;66;1051-66; 1909605

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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