Available to order

International strain nameD1.129P2(B6)-Il10tm1Cgn/JOrl
Alternative nameD1.B6-Il10tm1Cgn/J
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIl10tm1Cgn,
Gene/Transgene symbolIl10

Information from provider

ProviderPascale Plence
Provider affiliationINSERM U1183
Genetic informationA 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. Submitted mouse strain was obtained by backcrossing strain B6.129P2-Il10tm1Cgn/J, obtained by the Jackson Laboratory (strain ref. 002251), for 10 generations on DBA/1 background and followed by 3 intercrosses.
Phenotypic informationHomozygous:
Under conventional housing conditions, Il10-deficiency is associated with altered lymphocyte and myeloid profiles, elevated serum amyloid A levels, altered responses to inflammatory or autoimmune stimuli, increased prevalence of colorectal adenocarcinoma, and spontaneous development of chronic enterocolitis.

No phenotype
Breeding history10 backcrosses followed by 3 intercrosses
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous DBA/1

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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